Endocrine Abstracts

EEC is a multisystemic disease secondary to a clonal histiocyte proliferation of non-Langerhans cells due to hyperactivation of the MAPK/ERK signaling pathway, with somatic BRAF V600E mutation present in 50% of cases with therapeutic implications. Between 50% of patients develop endocrinopathies, the most frequent being central diabetes insipidus (CDI). We present the case of a 42-year-old woman, diagnosed with CDI in 1998 without family history, treated with DDAVP [MRI: absen...

Aim: To evaluate the response to growth hormone (GH) replacement in patients with growth hormone deficiency (GHD) after 1 year of treatment in terms of body composition, carbohydrate metabolism, lipid metabolism and quality of life.Method and patients: Twenty-eight patients with GHD with the following characteristics: 16 males, 10 with radiotherapy and 18 with panhypopituitarism, were included in our study. Body mass index (BMI) and waist hip ratio (WHR)...

Objective: The aim of this study was to evaluate maternal and perinatal outcomes before and after implementation of the International Association of Diabetes and Pregnancy Study Groups (IADPSG) criteria for testing of gestational diabetes mellitus (GDM).Methods: This is a retrospective cohort study of women with GDM followed at a single university hospital. We compared maternal and neonatal outcomes of singleton pregnancies in women with GMD before (from...

Introduction: Multiple endocrine neoplasia type 1 (MEN1) is a rare hereditary tumour syndrome inherited in an autosomal dominant manner and characterized by a predisposition to a multitude of endocrine neoplasms primarily of parathyroid, enteropancreatic, and anterior pituitary origin, as well as nonendocrine neoplasms. However, thyroid cancer is not part of this syndrome. Case details: We report the case of a 36-year-old man diagnosed with primary hyper...